摘要
目的:研究MIF和VEGF在上皮性卵巢癌组织及转移淋巴结和大网膜标本中的表达与临床病理的关系。方法:运用免疫组织化学法检测18例正常卵巢组织、24例良性卵巢肿瘤组织、42例上皮性卵巢癌组织(其中6例有淋巴结转移,16例有大网膜转移)及转移癌组织中MIF和VEGF表达情况。结果:卵巢癌组织MIF和VEGF阳性表达率与临床分期、组织学分级、远处转移有关,与病理类型无关。转移癌组织和原发癌灶中两者表达均无差异。MIF阳性表达率与VEGF阳性表达率呈现出一致的相关性。结论:MIF和VEGF参与了卵巢癌发生、发展、转移过程。MIF和VEGF表现出一定的正相关性,在卵巢癌发生和发展中呈协同一致作用。通过监测MIF和VEGF表达,可以判断肿瘤恶性程度。
Objective： To study the expression of MIF and VEGF in ovarian epithelial cancer tissues and metastatic lymph node and metastatic omentum and to explore the correlation between the expression of MIF, VEGF and clirdcopathologic features. Methods： The expressions of MIF and VEGF were detected by immuohistochemistry SP method, including 18 cases of normal ovarian tissues, 24casos of benign ovarian tissues and 42 cases of ovarian epithelial cancer tissues and 6 cases with metastatic lymph node and 16 cases with metastatic omentum. Results： MIF and VEGF were overexpressed in ovarian cancer. The expressions of MIF and VEGF were closely correlated with tumor differentiation, clinical staging and metahasis, hut were uncorrelatod with the pathological type. There was no difference between the positive expression of MIF and VEGF in distant place metastasis and in primary carcinoma within the ovary. There was a positive correlation between the positive rates of VEGF and the positive rates of MIF. Conclusion： MIF and VEGF play an significant role in carcinogenesis, growth of ovarian cancer and development of ovarian cancer. Malignant degree of the tumor could be judged by monitoring the expression of MIF and VEGF.
出处
《中国妇幼保健》
CAS
北大核心
2008年第29期4185-4187,共3页
Maternal and Child Health Care of China
