摘要
目的探讨应用吗替麦考酚(MMF)联合拉米夫定治疗乙型肝炎病毒相关性肾炎(HBV-GN)的临床疗效及安全性。方法收集我院乙型肝炎病毒相关性肾炎35例,给予MMF和拉米夫定口服治疗,观察治疗期间24 h尿蛋白定量、血清白蛋白、肝功能、肾功能、血脂及HBV-DNA定量,并记录不良反应情况。结果治疗后24 h尿蛋白量明显减少(P<0.05),血清白蛋白明显上升(P<0.05),SCr明显下降(P<0.05),未发现病毒复制增加。随访12个月治疗总有效率86%,完全缓解20例(57%),有效10例(29%),治疗期间未发现严重不良反应。结论初步观察显示MMF联合拉米夫定治疗HBV-GN不增加病毒复制的风险,安全有效。
Objective It is to observe the clinical efficacy and the adverse effects of mycophenolate mofetil（MMF） combined with lamivudine in treatment of patients with hepatitis b virus associated glomerulonephritis（HBV-GN）.Methods35 patients with HBV-GN were treated with MMF combined with lamivudine orally.24h excretion of proteinuria,serum albumin,liver function,renal function,blood fat and hepatitis b virus DNA（HBV-DNA） were assessed.The adverse effects were measured regularly.Results 24 h proteinuria excretion was significantly reduced by the treatment of mycophenolate mofetil and lamivudine（P〈0.05）.The serum albumin was significantly improved（P〈0.05）.Serum creatinine were remarkably reduced（P〈0.05）. The reproduction of HBV-DNA did not increase.The total effective rate was 86% after 12 months treatment,while 20 of 35 cases achieved complete remission（57%） and 10 cases partial remission（29%）.There were no serious adverse effects during the period of treatment.Conclusion The preliminary investigation demonstrates that MMF combined with lamivudine was effective and safe without increasing the risk of occurrence rate of HBV-DNA reproduction.
出处
《现代中西医结合杂志》
CAS
2008年第30期4674-4676,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
乙型肝炎病毒相关性肾炎
拉米夫定
吗替麦考酚
hepatitis b virus associated glomerulonephritis
lamivudine
mycophenolate mofetil
