摘要
不同剂量和强度的超声对细胞会产生一定生物效应。当超声参数设置合适时,能使细胞膜通透性明显增强。加入声学造影剂,由于造影剂中存在很多微泡,微泡在超声波的作用下被激活,泡核表现为振荡、生长、收缩及崩溃等一系列动力学过程,在此过程中局部产生高温高压,使细胞膜通透性进一步增强。细胞膜通透性增强能使细胞内物质释放,细胞外物质进入细胞,这样可用于释放代谢物质或中间产物,化学方法治疗肿瘤及基因转导等。根据近几年的研究,超声对细胞膜通透性的影响可以部分用于解释超声杀菌的机理,但这还有待于我们进一步的深入研究。
Different dosage of ultrasound could induced definite biologic effects. When set a suitable parameter of ultrasound, ultrasound could obviously increase the permeability of cell membrane. When join some ultrasound developer, because of the tiny air bubble existent in ultrasound developer could bring a series of dynamics course behaved as surging, developing, shrinking and crashing during the course coule produce hige power and high temperature on local, this could increase the cavitate effect , and more increase the permeability of cell membrane. Permeability of cell membrane increased , the substance existing in cell released out of ceil, and make the substance existing out of cell enter into the inside of cell. So using the permeability function of cell membrane, we could release metabolize substance or middle production , with chemistry method to treat turnout and gene transferring. Based on the study of recent years, the effect of ultrasound on permeability of cells could explain the mechanism of ultrasound sterilization in part. But this could be lucubrated for us.
出处
《菏泽学院学报》
2007年第5期67-69,103,共4页
Journal of Heze University
基金
国家自然科学基金资助项目(10074042
10474061)
关键词
超声
细胞膜
通透性
超声空化
ultrasound
cell membrane
permeability
ultrasonic cavitation
