摘要
目的探讨碱性成纤维细胞生长因子(bFGF)在肺鳞癌、腺癌组织中的表达及其与肿瘤微血管生成的关系。方法免疫组化法检测76例肺癌标本(肺鳞状细胞癌31例、肺腺癌45例)bFGF的表达及以CD34衡量的微血管增生情况。结果在76例标本中,53.9%的肿瘤组织标本检测到bFGF阳性表达,与TNM分期及淋巴结转移相关;同时发现肿瘤组织中微血管增生程度亦与肿瘤的TNM分型和淋巴结转移相关。结论bFGF分子在肺癌发生、发展中具有重要作用。
Objective To investigate the expression and distribution of basic fibroblast growth factor（bFGF） in human lung squamous cancer and glandular cancer. Methods The expression of bFGF in 76 patients with lung cancer （31 cases of lung squamous cancer and 45 cases of lung glandular cancer ） was examined using immunohistochemical methods, ,and the relationship between the expression and clinicopathological parameters were analyzed. Results The positive rates of bFGF in carcinoma tissue were 61.3% for squamous cancer and 48. 9% for glandular cancer. The expression of bFGF was associated with TNM stages, the condition of lymphatic metastasis and microvessel density. Conclusion bFGF may play an important role in tumor angiogenesis and lymphatic metastasis of human lung cancer.
出处
《江苏医药》
CAS
CSCD
北大核心
2008年第9期895-897,共3页
Jiangsu Medical Journal
