摘要
目的:应用超声心动图评定和区分病理性和生理性左室肥大。方法:20只雄性SD大鼠随机分为3组:训练组,8只SD大鼠完成8周大强度游泳训练;2K1C组,6只SD大鼠建立"两肾一夹"高血压动物模型;对照组,6只SD大鼠做假手术组。8周后,应用常规和组织多普勒超声心动图检测所有大鼠。结果:超声心动图结果显示2K1C组和训练组心脏重量左室室间隔以及左室后壁厚度均增加,左室质量分别增加36%和41%。二尖瓣瓣口血流速度显示训练组舒张晚期血流速度降低,从而导致舒张早期血流速度/舒张晚期血流速度(E/A)比值增加。但是2K1C组二尖瓣瓣口血流速度显示舒张晚期血流速度增加,从而导致E/A比值降低。训练组显著增加二尖瓣瓣环基底部和侧壁瓣环舒张早期运动速度(Ea)和舒张早期运动速度/舒张晚期运动速度(Ea/Aa)比值增加,但2K1C组二尖瓣瓣环基底部和测壁瓣环舒张晚期运动速度(Aa)显著增加,从而导致舒张早期运动速度/舒张晚期运动速度(Ea/Aa)比值降低。结论:左室舒张功能多普勒超声心动图参数对于区分病理性和生理性左室肥大具有重要诊断意义。
Objective：To examine the differential diagnosis between physiological and pathological left ventricular hypertrophy by using current echoeardiography techniques. Methods：Twenty male SD rats were randomly divided into three groups：One group of rats performed swimming training at high intensive swimming training （HIGH）;One group of rats, a 2KIC hypertension was created and maintained （2KIC）;And the third rats group was sham operation （control）. After 8 weeks,all rats were studied by standard and tissue Doppler echocardiography. Results：Echocardiography showed septal and posterior wall thickness increases in both the 2K1C and HIGH rats. Left ventricular increased by 36% and 41% respectively. Mitral inflow showed a decrease in late-wave velocity,thus increasing the E/A ratio in HIGH rats. However, mitral inflow showed an increase in late-wave velocity,thus decreasing the E/A ratio in 2K1C rats. There was a significant increase in Ea and Ea/Aa in HIGH rats in basal septum and lateral mitral valve annulus. And there was a significant increase in Aa,which led to significant decrease in Ea/Aa in 2K1C rats. Conclusion：Doppler echocardiography parameters of IN diastolic function can be of diagnostic importance for discrimination between pathologic and physiologic LV hypertrophy.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2008年第9期1124-1127,共4页
Journal of Nanjing Medical University(Natural Sciences)
关键词
生理性肥厚
超声心动图
运动强度
physiological hypertrophy
echocardiography
exercise intensity
