摘要
目的探讨中药注射剂致过敏性休克的流行病学特点。方法通过检索文献,收集中药注射剂致过敏性休克详细病案580例,并选择580例中药注射剂致非过敏性休克病案作为对照,应用文献计量学和统计学方法对中药注射剂致过敏性休克的流行病学特点进行分析。结果该组病例中,60～69岁年龄段患者的性别构成比与对照组存在显著性差异(P<0.05);双黄连注射剂过敏性休克患者的平均年龄显著高于对照组(P<0.05);穿琥宁注射剂过敏性休克患者的平均年龄显著低于对照组(P<0.05);过敏性休克的死亡率为5.34%.结论应进一步规范合理用药,增强预防意识,减少过敏性休克的发生。
Objective To investigate the epidemiological characteristics of Chinese herb injection-induced anaphylactic shock. Methods Domestic medical periodicals from the year of 1972 to 2007 were investigated. Five hundred and eighty cases of anaphylactic shock induced by Chinese herb injection and another 580 cases of non - anaphylactic shock were analyzed by lit- erature metrologic method and statistic method. Results The gender proportion in the age group of 60 - 69 years old differed from that in the control group （ P 〈 0.05） ; average age of patients suffering from anaphylactic shock caused by Shuanghuan- glian Injection is significantly higher than that in the control group （ P 〈 0.05） ; average age of patients suffering from anaphy- lactic shock caused by Chuanhuning Injection was significantly lower than that in the control group（ P 〈 0.05）; mortality of anaphylactic shock is 5.34 %. Conclusion To reduce the occurrence of anaphylactic shock induced by Chinese herb injec- tion, We should use Chinese herb injection more rationally and keep the prevention consciousness.
出处
《中药新药与临床药理》
CAS
CSCD
2008年第5期404-407,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
中药注射剂
过敏性休克
流行病学特点
Chinese herb injection
Anaphylactic shock
Epidemiological characteristics
