摘要
考察了新月弯孢霉(Curvularia lunata)AS3.3589、蓝色犁头霉(Absidia coerulea)CICC40302和雷斯青霉(Penicillium raistrickii)ATCC10490对洋地黄毒苷的生物转化特性.结果表明:新月弯孢霉AS3.3589转化洋地黄毒苷得到2个产物,即产物Ⅰ和产物Ⅱ,产物Ⅰ的转化率为27%,产物Ⅱ的转化率为5%;蓝色犁头霉CICC40302转化洋地黄毒苷得到1个产物,即产物Ⅲ,转化率为6%;雷斯青霉ATCC10490对洋地黄毒苷不发生转化反应.通过优化新月弯孢霉KA-91生物转化反应的工艺条件,使转化产物Ⅰ的转化率达到38%,产物Ⅱ的转化率达到10%.
Biotransformed identity of digitoxin is investigated by Curvularia lunata AS3.3589, Absidia coerulea CICC40302 and Penicillium raistrickii ATCC1049. Results of the experiment are these： Two products are gotten when digi- toxin is biotransformed by Curvularia lunata AS3.3589, named product Ⅰ and product Ⅱ, and the biotransformation yields are 27% and 5%; One product is gotten when digitoxin is biotransformed by Absidia coerulea CICC40302, named product Ⅲ, and the biotransformation yield is 6%; Penicillium raistrickii ATCCI049 can not biotransform digitoxin. The optimum conditions of transformation by Curvularia lunata AS3.3589 are studied by transformated experiment. After that, the bio- transformation yield of product Ⅰ is attained to 38% and of product Ⅱ is attained to 10%.
出处
《天津科技大学学报》
CAS
2008年第3期8-12,共5页
Journal of Tianjin University of Science & Technology
基金
天津市应用基础及前沿技术研究计划重点项目(08JCZDJC15200)
关键词
洋地黄毒苷
新月弯孢霉
蓝色犁头霉
雷斯青霉
生物转化
digitoxin
Curvularia lunata
Absidia coerulea
Penicillium raistrickii
biotransformation
