摘要
目的研究抗心磷脂抗体(ACA)及抗β2糖蛋白I抗体(aβ2GPI)对系统性红斑狼疮(SLE)患者发生血栓并发症的预测价值。方法对河北医科大学第二医院免疫风湿科2004年10月至2006年10月收治的45例活动期SLE患者用酶联免疫吸附法(ELISA)检测ACA及aβ2GPI水平。分析它们与SLE患者血栓发生率的关系。结果45例SLE患者中27例(60.0%)ACA阳性;其中10例并发血栓;ACA阴性的18例患者中1例并发血栓。ACA阳性与阴性的SLE患者间血栓发生率差异有统计学意义(P<0.05)。ACA对预测SLE患者发生血栓的敏感性为90%,特异性为50%。45例患者中17例(37.8%)aβ2GPI阳性,其中8例并发血栓;aβ2GPI阴性的28例患者中3例并发血栓。aβ2GPI阳性与阴性的SLE患者间的血栓发生率差异有统计学意义(P<0.01)。aβ2GPI预测SLE患者发生血栓的敏感性为72.7%,特异性为73.5%。结论ACA、aβ2GPI均与SLE的血栓形成相关,可用于预测SLE患者的血栓前状态。且aβ2GPI的特异性优于ACA,而敏感性不及ACA。
Objective To investigate the value of anticardiolipin antibody（ACA）and anti-beta 2 glycoprotein I antibody （ aβ2 GPI） in predicting thrombosis in patients with active SLE. Methods Samples were collected from 45 active SLE cases. Serum ACA and aβ2GPI were measured by enzyme-linked immunosorbent assay（ELISA）. Results Among 45 cases with active SLE, there were 27 （60%）patients with positive ACA and 10 with thrombosis. The rate of thrombosis was 37% （10/27）. There was only 1 with thrombosis in ACA negtive patients. The rate of thrombosis was 5.6% （ 1/18 ）. There was significant difference in thrombosis occurrence rate between ACA positive or not （ X^2 = 5. 795, P 〈 0. 05 ）. The sensitivity was 90% ,and the specificity was 50% for ACA in predicting SLE patients＇ occurrence of thrombosis. There were 17 （37.8%） patients with positive al32 GPI and 8 with thrombosis. The rate of thrombosis was 47.1% （8/17）. There were only 3 patients with thrombosis with negtive aβ2 GPI. The rate of thrombosis was 10. 7% （3/28）. There was significant difference in thrombosis occurrence rate between aβ2 GPI positive or not（ X^2 = 7. 565, P 〈 0. 01 ）. The sensitivity was 72.7%, and the specificity was 73.5% for aβ2GPI in predicting SLE patients＇ occurrence of thrombosis. Conclusion ACA and aβ2GPI all correlate with thrombosis in SLE, so their measurements may be useful for predicting the occurrence of thrombosis in SLE. ACA is more sensitive,but less specific than aβ2GPI.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2008年第9期757-758,共2页
Chinese Journal of Practical Internal Medicine
关键词
系统性红斑狼疮
抗心磷脂抗体
抗Β2糖蛋白I抗体
血栓
systemic lupus erythematosus
anticardiolipin antibody
anti-beta 2 glycoprotein I antibody
thrombosis
