摘要
目的分析伽玛刀治疗复发性前列腺癌的治疗效果。方法31例复发性前列腺癌患者，伽玛刀治疗以60％～70％等剂量线包绕计划靶区；剂量每次3．8-5．0Gy，治疗次数为10～13次，总放射剂量41．8～55．0Gy．每日或隔日治疗。其中，13例同时及伽玛刀治疗后配合内分泌药物治疗。结果治疗后随访期内前列腺特异性抗原值达到完全缓解19例，前列腺特异性抗原值达到部分缓解10例；结束治疗后3个月影像学检查总的有效率为74．2％（23／31）。3年总的生存率为61．3％。配合内分泌药物治疗和未配合内分泌药物治疗的3年生存率分别是61．5％和61．1％。随访期内未见严重放射性并发症。结论对复发性前列腺癌采用伽玛刀治疗是较有效的局部治疗方法。
Objective To investigate the clinical effects of γ-knife for recurrent prostate cancer. Methods Thirty-one patients with recurrent prostate cancer were treated from December 2002 to June 2005. All patients were treated by γ-knife,and 60%-70 % isodose curve including 95 % PTV was delivered at 3.8-5.0 Gy every time,10-13 times in total,with the total doses of 41.8-55.0 Gy. Thirteen patients were treated with y knife combined with endocrinothergy. Results Nineteen patients obtained CR of PSA value. Ten patients obtained PR of PSA value. Three months after treatment,the over response rate evaluated by CT or MRI was 74. 2% （23/31）. The total survival rate at 3 years was 61.3 %. The survival rate of γ-knife combined with endocrinotherapy at 3 years was 61.5%. The survival rate of γ-knife alone at 3 years was 61.1%. No serious complications were found in the follow up period. Conclusion γ-knife is an effective treatment for recurrent prostate cancer.
出处
《海军总医院学报》
2008年第3期139-141,共3页
Journal of Naval General Hospital of PLA
关键词
前列腺癌
伽玛刀
Prostate cancer
γ-knife
