摘要
抗甲状腺药物丙基硫氧嘧啶（PTU）可引起针对多种靶抗原的抗中性粒细胞胞浆抗体（ANCA）阳性，进而导致系统性小mL管炎（AASV），最常累及肾脏，多表现为寡免疫复合物型急进性肾小球肾炎。IgA肾病以肾小球系膜区IgA沉积为特点，ANCA刚性可能是其预后不良的一个指标，但目前尚无证据表明PTU致ANCA阳性可引起IgA肾病，多数学者仍认为两者是并存的关系。
Propyhhiouracil （PTU） ,which is used as an anti-hyperthyroidism drug,can induce antineutropbil cytoplasmic antibody （ANCA） against multiple antigens, and lead to ANCA-associated system vasculitis （AASV）. Kidney is one of the important organs to be involved. ANCA-positive renal disease often displays as pauei-immune rapidly progressive glomendonephritis. IgA nephropathy is characterized by IgA sediment in mesangial regions,and ANCA may be a negative index to the prognosis of IgA nephropathy. So far, there is no evidence to prove that ANCA could induce IgA nephropathy. It is considered to be a concurrent relationship between PTU-induced ANCA and IgA nephropathy.
出处
《国际内分泌代谢杂志》
2008年第5期300-302,共3页
International Journal of Endocrinology and Metabolism
基金
江苏省神会发展基金（BS2004039）
