摘要
目的:研究复春散在大面积烧伤患者创面愈合过程中的抗菌效果及促愈合、抗疤痕作用。方法:将2004年5月-2006年6月收入本院的大面积烧伤患者39例,随机分为治疗组20例和对照组19例,两组均行早期切削痂植皮手术。待创面大部分愈合后,治疗组采用复春散混悬液(浓度为10%)浸洗创面15～30min,再用1%磺胺嘧啶银霜(SD-Ag)外敷包扎,每日或隔日换药;对照组采用温水浸洗15～30min,再用1%磺胺嘧啶银霜外敷包扎,每日或隔日换药。观察创面的变化及愈合情况,并做细菌学调查。将数据资料经SPSS11.0软件分析。随访观察疤痕增生情况,部分病例组织标本送病理。结果:治疗组烧伤创面平均愈合时间为(26.75±2.50)d,对照组为(33.81±2.42)d,两组差异有统计学意义(P<0.05),治疗组创面细菌检出率明显下降(P<0.05),且临床大体及病理切片示疤痕增生较轻。结论:复春散能够抑制创面细菌感染,缩短创面愈合过程,减少疤痕增生,可以作为大面积烧伤患者创面的局部用药。
Objective： To explore the use of Fuchunsan regarding its antimicrobial efficacy as well as benefits to promote healing and prevent scars over the treatment course of extensive burns. Methods： From May 2004 to Jun 2006, thirty -nine cases of extensive burns admitted to our hospital were randomized into the experimental group （n=20） and control group （n=19）. The both group underwent early excision or shaving of the eschars plus skin grafting. Once the wounds were healed for the most part, the patients received once-daily or once another day dressing with 1% silver sulfadiazine cream after a 15 -30 minute topical bath in Fuchunsan suspension （treatment group） or in warm water （control group）. The appearance, healing and microbiological status of the wounds were reeorded and analyzed with the SPSS 11.0 statistical package. Scarring of the wounds was followed up, and in some of the patients, tissue biopsies were performed. Results ： The mean duration to complete healing in the treatment group was （26.75±2.50） days vs （53.81±2.42） days in the control group （P〈0.05）. Patients treated on Fuehunsan experienced significantly lower rate of positive culture and milder scarring as compared with the controls. Conclusion： Fuchunsan appears effective to inhibit bacterial infection, promote healing and improve scarring, which may justify its topical use for treatment of extensive burns.
出处
《广州医学院学报》
2008年第2期44-46,共3页
Academic Journal of Guangzhou Medical College
关键词
复春散
烧伤
创面感染
fuchunsan
burns
wound infection
