摘要
目的:探讨多普勒超声血流仪检测糖尿病下肢血管病变(LEAD)的临床意义。方法:采用ES-1000SPM多普勒超声血流仪检测470例2型糖尿病患者双下肢动脉,观察踝/肱指数(ABI)、足背动脉或胫后动脉搏动指数(PI)、阻力指数(RI)。根据ABI值将受检者分为动脉钙化组(ABI>1.3)、非LEAD组(1.0≤ABI≤1.3)、轻度缺血组(0.8≤ABI<1.0)、中度缺血组(0.5≤ABI<0.8)、重度缺血组(ABI<0.5),同时检测各组患者的糖化血红蛋白(HbA1C)、低密度脂蛋白胆固醇(LDL-C)、收缩压(SBP)。结果:糖尿病患者检测出164例(34.9%)LEAD;与非LEAD组比较,轻、中、重度缺血组患者PI值明显降低,而RI值明显升高,差异均有显著性意义(P<0.05);相关分析发现,下肢缺血性病变患者的ABI值与HbA1C、LDL-C、SBP均呈明显负相关(P<0.05)。结论:多普勒超声血流仪可作为临床早期筛查糖尿病LEAD的有效手段,高血糖、高血脂、高血压可能是引起LEAD的危险因素。
Objective： To investigate the clinical significance of diabetic lower-extremity arterial disease （LEAD） ＇s detection with color Doppler ultrasonography. Methods： A total of 470 cases of type 2 diabetic lower-extremity arteries were detected with ES-1000SPM Doppler ultrasound equipment. The ankle/brachium index （ABI）, arteria dorsalis pedis or arteria tibialis posterio’s pulsatility index （PI） and resistent index （RI） were measured. According to ABI, all subjects were divided into five groups as arteriosteogenesis group （ABI〉1. 3）, none-LEAD group （1.0≤ABI≤1. 3）, mild-ischemia group （0.8≤ABI〈1. 0）, mid-ischemia group （0.5≤ABI〈0.8） and severe-ischemia group （ABI〈0.5）. At the same time, glycosylated hemoglobin （HbA1c）, low density lipoprotein cholesterol （LDL-C） and systolic blood pressure （SBP） were also detected. Results： Of the 470 cases, 164 cases of LEAD were detected （34.9%）. Compared with that in none-LEAD group, PI decreased significantly in mild-ischemia group, mid-ischemia group and severe-ischemia group （all P〈0.05）, then their RI increased significantly （P〈0.05）. Correlation analysis discovered that ABI showed a strong negative correlation with HbA1c, LDL-C and SBP among patients with LEAD（P〈0.05）. Conclusion： Color Doppler ultrasonography is a good method for
出处
《武汉大学学报（医学版）》
CAS
2008年第5期677-679,共3页
Medical Journal of Wuhan University
关键词
2型糖尿病
下肢血管病变
多普勒
超声
Type 2 Diabetes Mellitus
Lower-Extremity Arterial Disease
Doppler
Ultrasound
