摘要
目的:建立消咳宁片中盐酸麻黄碱的含量测定HPLC方法。方法:色谱柱为phenomenes C_(18)柱(200mm×4.6 mm,5μm),流动相为乙腈-水-磷酸-三乙胺(3∶97∶0.1∶0.1),流速为1.0 ml·min^(-1),检测波长为206 nm。结果:盐酸麻黄碱在0.04～0.80μg范围内线性关系良好(r=0.999 8),平均回收率为97.5%(RSD=0.5%)。结论:方法灵敏、准确、专属性强.适用于该制剂的质量控制。
Objective： To establish a method for determination the content of ephedrine hydrochloride in Xiaokening Tablets by HPLC. Method： The phenomenes C18 column（ 200 mm × 4.6 mm ,5 μm）was used, the mobile phase was acetonitrile-water-phosphorie acid-triethanolamine （3：97：0.1：0.1）, the flow rate was 1.0 ml· min-1, and the detection wavelength was 206 nm. Result： The linear range of ephedrine hydrochloride was 0.04 -0.80 μg（ r =0. 999 8）, the average recovery was 97.5% （RSD =0.5% ） . Conclusion： The method is sensitive, simple, accurate, and specific. It can be used for the quality control of Xiaokening tablets.
出处
《中国药师》
CAS
2008年第9期1065-1066,共2页
China Pharmacist
