摘要
急性胆道感染是肝胆外科常见的危重疾病,是引起脓毒症、多器官系统衰竭(multipleorgan system failure,MOSF)和患者死亡的常见原因.胆道系统可通过物理、化学和免疫等机制防御感染,Kupffer细胞(KC)是机体单核吞噬细胞系统的重要组成部分,是防御胆道感染的天然屏障,在胆道感染的发生发展和防治中起着十分重要的作用,并得到越来越多的重视.如何调控急性胆道感染时KC的功能,预防和减少MOSF的发生是今后研究的重点和方向.本文就KC在胆道感染中的作用作一综述.
Acute infection of biliary tract was a frequent severe case in hepatobiliary surgery and also a common cause of sepsis, multiple organ system failure （MOSF） and even death. The biliary system could suppress infection through physical, chemical and immune mechanisms. Kupffer cell （KC） is an important ingredient of the monocyte- phagocyte system and also a natural barrier against the infection of biliary tract, thus plays an important role both in the development and prevention of biliary tract infection, How to regulate the function of Kupffer cells and prevent multiple organ system failure in biliary duct infection are the most important problems to be solved.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第24期2746-2750,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30471696~~
