摘要
目的探讨肝硬化腹水患者血浆、腹水中内毒素(LPS)和一氧化氮(NO)水平及其与自发性细菌性腹膜炎(SBP)的关系。方法采用鲎试剂三肽显色基质偶氮法及硝酸还原酶法检测30例正常人的血浆、42例肝硬化腹水患者血浆、腹水LPS和NO水平。结果无论有无合并SBP,肝硬化患者的血浆LPS、NO水平均明显高于对照组(P<0.01),而合并有SBP组的血浆及腹水内毒素和NO水平明显高于未合并SBP组(P<0.01)。结论检测血浆及腹水中的LPS和NO水平有助于早期诊断SBP,对指导临床治疗以及判断疗效有一定作用。
Objective To investigate the changes of Lipopolysaccharides （LPS） and NO in plasma and ascites of patients with liver cirrhosis （LC） complicated with spontaneous bacterial peritonitis （SBP） and their clinical significance. Methods The level of LPS was assayed by limulus amebocyte lysate test and the level of NO was evaluated with the kit of nitrate reductase in plasma and ascetic fluid. Results Whether with or without SBP, the levels of LPS and NO in plasma and ascitic were significandy higher in liver cirrhotic patients than those in healthy control group（ P 〈0.01 ） ,and they were higher in cirrhosis with SBP than those without SBP （P 〈0.01）. Conclusion The detection of fluid LPS and NO in plasma and aseitic has an important value in early diagnosis and judgement of prognosis of SBP in liver cirrhosis.
出处
《咸宁学院学报（医学版）》
2008年第3期204-206,共3页
Journal of Xianning Univarsity(medical Sciences)
关键词
内毒素
一氧化氮
肝硬化
自发性细菌性腹膜炎
Lipopolysaceharide endotoxin
NO
Liver cirrhosis
Spontaneous bacterial peritonitis
