摘要
探讨肝硬化自发性腹膜炎 (SBP)患者体内内毒素、TNF -α、IL - 6水平变化及乳果糖治疗的临床意义。将 34例SBP患者随机分为标准治疗对照组和乳果糖治疗组。同时设肝硬化无菌性腹水 (SA)对照组 (11例 )和健康对照组 (11例 )。于治疗前后 ,对患者血液标本分别采用鲎试剂三肽显色基质偶氮法、双抗体夹心酶联免疫吸附法检测内毒素水平、TNF -α、IL - 6水平。治疗前SBP组、SA组血浆内毒素、TNF -α、IL - 6浓度均显著高于健康对照组 (P值均 <0 0 0 1)。治疗后乳果糖治疗组血浆内毒素、TNF -α、IL - 6浓度较标准治疗对照组下降明显 (P <0 0 5 )。Pearson相关性分析 :肝硬化腹水患者血浆内毒素、TNF -α及IL - 6水平相互正相关 (P <0 0 0 1)。乳果糖短期治疗可以显著降低肝炎肝硬化SBP患者血浆内毒素、TNF -α、IL -
To evaluate the therapeutic effects of Lactulose in cirrhotic patients with spontaneous bacterial peritonitis (SBP). 34 SBP patients of hepatitis cirrhosis were randomized into two groups: a treating group with lactulose and a control treating group based on oral administration of lactulose or not. All cases were observed for 7days. In additiion, 11 cirrhotic patients with sterile ascitic fluid (SA) were sorted into cirrhosis SA control group. 11 healthy cases were sorted into healthy control group. The plasma levels of tumor necrosis factor-α (TNF-α), interleukine 6(IL-6) were measured with a double monoclonal sandwich enzyme linked immunosorbent assay (ELISA). The plasma levels of endotoxin(LPS) were measured with limulus amebocyte lysate test. (1)The plasma levels of TNF-α, IL-6 and LPS were significantly higher in hepatitis cirrhosis patients with SBP than those without SBP in admitting hospital (P<0.05). And they were higher in cirrhosis without SBP than those in healthy control group (P<0.05). (2)After being treated for one week, the plasma levels of TNF-α, IL-6 and LPS were significantly decreased in lactulose treatment group than those in standard treatment group (P<0.05). (3)By Pearson correlation, in SBP patients, the plasma level of LPS had significantly correlated with the level of TNF-α and IL-6 (P<0.001). Oral lactulose is beneficial to hepatitis cirrhotic patients with SBP, by reducing endotoxin and cytokines levels in plasma.
出处
《临床肝胆病杂志》
CAS
北大核心
2004年第6期353-355,共3页
Journal of Clinical Hepatology
