摘要
目的观察氟替卡松(FP)与布地奈德(BUD)治疗婴幼儿哮喘的疗效。方法收集本院哮喘门诊哮喘婴幼儿105例。男68例,女37例;年龄1～35个月,平均16个月。随机分为FP组、BUD组、对照组,每组各35例。3组患儿性别、年龄及病情分度均无显著差异,具有可比性。根据病情轻、中、重度,FP组与BUD组每天吸入相应的药物,剂量均分别为1喷、2喷、3喷,对照组仅予对症治疗。在首次处方药物时,由哮喘门诊专业护士指导操作,让家长掌握正确用药方法,以后随访时检查家长的操作是否正确,及时纠正错误,保证药物的准确应用。定期随访2a,记录各项观察指标,总结吸入治疗的有效性和安全性。结果经2a随访,FP组完成32例病例随访,BUD组完成28例病例随访,对照组完成34例病例随访。FP组与BUD组2a疗效相近,二者比较无显著差异;与对照组比较,在减少咳、喘天数方面,FP组在0.5a即显示出明显优势;随访1a,BUD组也显示出此类优势。FP组在减少哮喘发作次数方面与对照组也有显著差异。随访2a,FP组与BUD组间无显著差异,在减少咳、喘天数及减少哮喘发作次数均明显优于对照组。结论FP与BUD均可有效治疗婴幼儿哮喘。
Objective To observe the therapeutic effect of inhaled fluticasone（FP） and budesonide（BUD） on infants with asthma.Methods One hundred and five asthmatic children were selected in this study at the asthma clinic,which consisted of 68 boys and 37 girls,aged from 1 to 35 months.All patients were assigned randomly into 3 groups：FP treated group,BUD treated group and control group,35 patients were recruited in each group.The distribution of sex,age and the severity of patients in each group were not significantly different.The patients in FP group or BUD group received different doses,1,2 and 3 pulses respectively according to the degree of the disease（mild,mode-rate,severe）,the control group only received treatment aiming at symptoms.At the first visit,the parents of the asthmatic children were demonstrated how to use the medicine rightly,and corrected by the nurses in the asthma clinic if there were any mistakes in using by the parents at the follow-up visit.All patients were followed up for 2 years,and the effects of inhaled FP and BUD on asthma were compared.Results Thirty-two,28 and 34 patients were available in FP,BUD treated groups and control group respectively after 2 years of follow-up.The effect of FP and BUD group was similar.FP showed certain advantage in reliving cough and wheezing compared with control group after 0.5 year.BUD showed the same effectivity after 1 year as well.FP also reduced the attacks of asthma after 1 year.After 2 years,either FP or BUD reduced the days of cough,wheezing and the attacks of asthma.Conclusion Both FP and BUD demonstrated significant effect in treating asthma and can be used to treat asthma in clinical practice.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2008年第16期1280-1282,共3页
Journal of Applied Clinical Pediatrics
