摘要
目的探讨人乳头状瘤病毒（humanpa pillomavirus，HPV）分型检测在宫颈细胞学诊断为不典型鳞状细胞意义不明确（atypical squamous cell of undetermined significance，ASCUS）分层处理中的意义。方法对184例宫颈细胞学诊断为ASCUS的患者，分别进行HPV检测和阴道镜下宫颈组织活检。结果184例宫颈细胞学诊断为ASCUS的患者中，经组织病理学证实炎症112例（60．87％），CINI级33例（17．93％），CINⅡ级17例（9．24％），CINⅢ级8例（4．35％），宫颈鳞癌4例（2．17％），宫颈湿疣10例（5．43％）。其中124例经检测呈高危型HPV（high-risk types HPV，HR-HPV）阳性，阳性率为67．39％（124／184），随后经病理学证实炎症66例（53．23％），CINI级22例（17．74％），CINⅡ级16例（12．9HD％），CINⅢ级8例（6．45％），宫颈鳞癌4例（3．23％），宫颈湿疣8例（6．45％）。HPV阳性组CIN以上病变检出率明显高于HPV阴性组（P〈0．003）。结论对宫颈细胞学诊断为ASCUS的患者，建议作HPV检测，若HR-HPV阳性，则需进一步阴道镜下宫颈活检；若HPV阴性，酌情处理。
Objective To investigate the significance of human papillomavirus test in triage of patients with atypical squamous cell of undetermined significance （ASCUS） diagnosed by cervical cytology. Methods Human papillomavirus test,colposcope and cervical biopsy were performed in 184 patients with a referral diagnosis of ASCUS by cervical cytology. Results Confirmed by pathological diagnosis of cervical biopsy, 112 cases were chronic inflammation（60.87%）,33 CIN Ⅰ（17.93%）,17 CIN Ⅱ （9.24%）,8 CIN Ⅲ （4.35%）,4 cervical squamous carcinoma （ 2.17% ） and 10 condyloma （ 5.43% ）. Of the 184 women with cytological ASCUS, 124 （67.39%） cases were positive in high-risk HPV test among which 66 cases were histologically confirmed as chronic inflammation（53.23% ）,22 as CIN Ⅰ （17.74%）, 16 as CIN Ⅱ （12.90%）,8 as CIN m （6.45%）,4 as cervical squamous carcinoma （3.23%） and 8 as condyloma（6.45%）. The positive rate of HPV in groups of ASCUS were higher than those with negative HPV （ P 〈 0.003）. Conclusion Women with ASCUS should be tested for HPV. Cervical biopsy under colposcopy is recommended for women with HR-HPV infection.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
北大核心
2008年第4期299-301,共3页
Chinese Journal of Experimental and Clinical Virology
基金
国家科委资助项目（Y0204003040731）：国家“十五”攻关科研基金资助项目（2004BA720A05-01）
