摘要
In weak acid medium,a significant enhancement of resonance Rayleigh scattering(RRS) spectrum and new RRS spectra were observed when amikacin reacted with acid bisazo dye trypan blue and new RRS spectra with amaximum peak at 717nm.The characteristic of RRS spectra,the optimum conditions for the reaction and the influencing factors were studied.The concentration of amikacin in the range of 0～6.24μg/mL is linear to the resonance scattering intensity(IRRS)at 717nm.The detection limit(3σ) of this method for Amikacin Sulphate is 9.2 ng·mL-1.Therefore,a simple,high sensitivity,good selectivity and repeat method for the determination of Amikacin Sulphate injection samples by RRS is developed with satisfactory results.
In weak acid medium,a significant enhancement of resonance Rayleigh scattering（RRS） spectrum and new RRS spectra were observed when amikaein reacted with acid bisazo dye trypan blue and new RRS spectra with amaximum peak at 717nm. The characteristic of RRS spectra, the optimum conditions for the reaction and the influencing factors were studied. The concentration of amikaein in the range of 0 - 6.24μg/mL is linear to the resonance scattering intensity （lass ）at 717nm. The detection limit （3σ） of this method for Amikaein Sulphate is 9. 2 ng · mL^-1. Therefore, a simple, high sensitivity, good selectivity and repeat method for the determination of Amikaein Sulphate injection samples by RRS is developed with satisfactory results.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2008年第8期1043-1046,共4页
Chemical Research and Application
基金
国家自然科学基金项目(20762017)
关键词
阿米卡星
曲利本蓝
共振瑞利散射
Amikacin
Trypan blue
Resonance Rayleigh Scattering
