摘要
目的探讨腺苷预处理对婴幼儿法洛四联症(TOF)根治术中肌钙蛋白Ⅰ(cTnI)和肌酸磷酸激酶同工酶(CK-MB)的影响。方法将120例体外循环下行TOF根治术的婴幼儿随机分为治疗组60例和对照组60例,治疗组在转流前应用腺苷,观察两组患儿恢复窦性心律的时间和多巴胺的平均用量,另分别于转流前、开放循环后30min和术后12h测定血清cTnI、CK-MB水平并进行比较。结果两组患儿的多巴胺用量间差异有统计学意义(P<0.01)。腺苷组开放循环后30min、术后12h的血清cTnI、CK-MB水平分别与对照组开放循环后30min、术后12h比较,差异有统计学意义(P<0.01)。结论腺苷预处理可以降低行TOF根治术患儿血清cTnI和CK-MB水平,对心肌具有良好的保护作用。
Objective To investigate the effects of exogenous adenosine preconditioning on cardiac truponin I （ cTn I） and creatine phosphate kinase- MB （CK -MB） infants with tetralogy of fallot （TOF） undergoing open heart surgery. Methods Totally 120 patients with TOF undergoing open heart surgery were randomly divided as trial group and control group. Adenosine preconditioning was elicited in the trial group before the cardiopulmonary bypass. The restoration time of sinoatrial node and average amount of dopamine were measured, and the levels of serum cTnI and CK - MB were determined in each group before the cardiopulmonary bypass, 30 rain after the aorta off damping and 12 hours after operation. The results between the two groups were compared. Results There was significant difference in dosage of dopamine between trial group and control group （ P 〈 0. 01 ）. There were significant differences in the levels of serum cTnI and CK - MB between trial group and control group 30 rain after the aorta off clamping and 12 hours after operation （ P 〈 0.01 ）. Conclusion Adenosine preconditioning can reduce the levels of serum cTnI and CK - MB in infants with TOF undergoing open heart surgery, and is of good myocardial protection.
出处
《中国全科医学》
CAS
CSCD
2008年第17期1539-1540,共2页
Chinese General Practice
基金
河北省科技厅技术攻关项目(052761246)
