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慢性缺氧对内源性腺苷含量变化的影响 被引量:1

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摘要 目的:观察内源性腺苷含量在慢性缺氧性肺动脉高压中的动态变化和可能作用。方法:50只雄性Sprague-Dawley大鼠随机分成对照组及缺氧7、14、21、28d组,每组10只。测各组大鼠平均肺动脉压、右心室肥大指数,用HPLC法测定右心室心肌内源性腺苷含量。结果:缺氧7d组大鼠内源性腺苷含量升高,与对照组比较差异有显著性(P<0.05),并随着缺氧时间的延长而增加(P<0.01)。但缺氧14d组和缺氧21d组间差异无显著性。缺氧性肺动脉高压、右心室肥大于缺氧7d后出现。结论:缺氧诱导内源性腺苷含量变化可能在大鼠缺氧性肺动脉高压中起重要作用。
出处 《实用医学杂志》 CAS 2008年第19期3314-3316,共3页 The Journal of Practical Medicine
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