摘要
目的选取盐酸氯胺酮,重组人干扰素α1b以及人狂犬病免疫球蛋白治疗带毒犬,力图为犬伤后寻找有效治疗。方法取经过盐酸氯胺酮,重组人干扰素α1b以及人狂犬病免疫球蛋白治疗的带毒犬唾液,采用快速狂犬病酶联免疫诊断(RREID),检测唾液标本中狂犬病病毒抗原转阴率分别为36.36%,7.14%,和10.00%。结果氯胺酮治疗组与干扰素及免疫球蛋白治疗组比较,病毒抗原转阴率差异有统计学意义(P<0.05)。结论盐酸氯胺酮在处理严重的犬咬伤抗狂犬病毒上具有一定效果。
In order to offered an effective treatment for human after bitten by dogs, ketamine recombinant human interferon α1b and human rabies immunoglobulin were used to treat those dogs infected by rabies virus. The saliva from the treated dogs was detected for the antigen of rabies virus by using Rapid Rabies Enzemy Immune-Diagnosis （RREID） method with the Pasteur diagnosis kit. The negative conversion rate of antigen was 36.36%, 7. 14% and 10.00% respectively. The results showed that the difference of negative conversion rate of antigen between group treated by ketamine and group treated by recombinant human interferon α1b or human rabies immunoglobulin had statistic significance （P〈0.05）. It is evident that ketamine is effect as treatment drug, on serious dog＇s biting.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2008年第8期757-759,共3页
Chinese Journal of Zoonoses
