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脑电双频指数在丙泊酚闭环反馈靶控输注复合瑞芬太尼全凭静脉麻醉的应用 被引量:10

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摘要 目的探讨脑电双频指数(BIS)作为丙泊酚闭环靶控输注的反馈控制变量复合瑞芬太尼在全凭静脉麻醉的应用。方法60例ASAⅠ-Ⅱ级择期拟需全身麻醉腹部肿瘤手术的患者。随机分为闭环靶控输注组(闭环组)和靶控输注组(靶控组),每组30例。两组丙泊酚血浆靶控浓度设定为3.0μg/ml,瑞芬太尼血浆靶控浓度设定为4.0.g/ml。术中闭环组丙泊酚浓度根据BIS反馈值50调节。记录两组在麻醉前、插管后3min、切皮、术中探查、切除肿瘤时,缝皮等时间点的MAP,HR,BIS变化及丙泊酚的用量。结果两组在插管后各时间点的MAP和HR下降明显(P〈0.05),靶控组MAP和HR变化幅度大于闭环组(P〈0.05),靶控组BIS值波动范围也大于闭环组(P〈0.05),闭环组丙泊酚用量明显少于靶控组(P〈0.01)。结论丙泊酚闭环靶控输注以BIS为反馈值复合瑞芬太尼用于全凭静脉麻醉,具有麻醉深度易维持、安全有效及节约费用等优点。
出处 《广东医学》 CAS CSCD 北大核心 2008年第9期1539-1540,共2页 Guangdong Medical Journal
基金 广东省惠州市科技局科研立项项目(编号:2008Y016)
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参考文献5

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