摘要
背景与目的:评价复脑苏在妊娠期的毒性。材料与方法:用82只SD大鼠孕鼠,分为3个不同剂量的复脑苏(7.5mg/kg、15.0mg/kg、30.0mg/kg)实验组,同时设阴性对照组(0.85%NS),每组19~21只孕鼠,实验组和对照组给药容量为10ml/kg体重。实验组和阴性对照组均采用尾静脉给药,给药时间为妊娠期第6d^15d。于妊娠第20d处死孕鼠,检查妊娠母体与胎鼠畸形情况。结果:复脑苏在各剂量组的活胎率、死胎率和吸收胎率及致畸率与对照组相比较差异无统计学意义(P>0.05);各实验组胎鼠体重、身长、尾长与对照组比较差异也无统计学意义(P>0.05);实验组的平均胎盘重与对照组相比较差异均具有统计学意义(P<0.05),但无明显的剂量-效应关系。各实验组除尾椎数和远端趾骨数与对照组相比差异具有统计学意义外(P<0.05),其它骨骼发育与对照组比较差异均无统计学意义(P>0.05)。各实验组均未观察到母鼠和胎鼠明显的外观、脏器以及骨骼的畸形。结论:复脑苏在本实验剂量(≤30.0mg/kg)下无明显的母鼠毒性和致畸作用,也无明显的胚胎毒性和胎鼠毒性。
BACKGROUND AND AIM： To study the teratogenic toxicities of carthamus in SD rats during the period of organ formation. MATERIALS AND METHODS： Eighty-two pregnant SD rats were randomly divided into four groups with about 20 rats in each, three carthamus dosage groups （7.5, 15.0, 30.0 mg/ kg）, and one negative control group. carthamus or normal saline was given via vena caudalis injection for 10 days during the period of organ formation （the 6th to 15th day of gestation） . The rats were sacrificed to examine the fetuses on the 20th day. RESULTS： Carthamus didn＇t produce significant difference on living fetuses ratio, absorbed fetuses ratio, dead fetus ratio, body length, tail length and weight of fetuses . There were statistical differences on average weight of placenta ,number of caudal vertebra and distant digital bone between treated groups and the negative control group. It didn＇ t induce any teratogenic effect on the appearance, bones and bowels of the fetuses when used under 30.0 rag/ kg. CONCLUSION： Carthamus had no maternal toxicity, teratogenic toxicity, embryotoxicity and fetotoxicity when used under 30.0 mg/kg.
出处
《癌变．畸变．突变》
CAS
CSCD
2008年第4期325-327,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
复脑苏
母体毒性
致畸作用
胚胎毒性
胎儿毒性
carthamus
maternal toxicity
teratogenesis
embryotoxicity
fetotoxicity
