摘要
目的定量检测慢性心力衰竭（CHF）病人血浆N端B型钠尿肽（NT—proBNP）水平，分析其与中医分型间的相关性，探讨NT—proBNP作为CHF中医辨证分型客观指标的可行性。方法306例纽约心脏病学会（NYHA）心功能分级Ⅱ级～Ⅳ级的CHF病人入院后行中医辨证分型，用化学发光方法测定血浆NT—proBNP水平。NYHA心功能分级变化≥1个级别时，再次进行中医辨证分型和NT—proBNP测定。共获得408份CHF病人的完整资料。采用Spearman相关分析检验不同中医证型与NT—proBNP的相关性。结果CHF病人总体（n=408）血浆NT—proBNP水平显著高于健康对照组（n=72，Z=-12．788，P＜0．05）；NT—proBNP水平随心力衰竭加重而上升，与NYHA分级呈正相关（Spearman相关分析，偏相关系数r=0．7494，P〈0．05）；NT—proBNP水平按心气虚兼血瘀证→心气阴两虚兼血瘀证→心脾阳虚兼血瘀水停证→心脾肾阳虚水饮泛滥证顺序增加（r=0．7061，P〈0．05）。结论NT—proBNP作为CHF中医辨证分型的生物学指标之一具有可行性。
Objective To investigate the possibility of NT - proBNP as a biological marker for traditional Chinese medicine （TCM） Syndrome types and to analyze relation between serum NT - proBNP level and TCM syndrome types in patients （pts） with chronic heart failure （CHF）. Methods The clinical data of 306 pts with CHF （ Ⅱ-IV grade of NYHA） were analyzed with TCM syndrome differentiation, and serum NT - proBNP level was analyzed quantitatively with chemical luminescence method. When NYHA classification change more than 1 stage, TCM Syndrome differentiation and serum NT - proBNP determination were re - performed, and a total of 408 individual data were completed. The correlation between NT - proBNP and TCM Syndrome types was accessed by Spearman Correlation Analysis. Results Serum NT - proBNP concentrations in pts with CHF （n= 408） were significantly higher than that in healthy controls（n= 72, Z=- 12. 788, P〈0.05）. NT - proBNP concentrations increased with CHF severity and were positively correlated with the NYHA classification system （r= 0. 749 4,P〈0.05）. NT - proBNP concentrations were positively correlated with TCM Syndrome typing （r=0. 706 1, P〈0.05）. Conclusion NT-proBNP concentrations might be a biological marker for TCM syndrome type determination in pts with CHF.
出处
《中西医结合心脑血管病杂志》
2008年第8期883-885,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
中国中医科学院中医优势病种项目资助(No.CACMS05Y007)
关键词
慢性心力衰竭
中医证型
N端B型钠尿肽
chronic heart failure
TCM syndrome types
N terminal B type natriuretic peptide （NT- proBNP）
