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胃良恶性病变组织中CD24和CD44v6的表达及其意义 被引量：3

Expression of cancer stem cell antigens (CD24,CD44v6) and its clinicopathological significance in the benign and malignant lesions of stomach
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摘要 目的:研究胃良恶性病变组织中癌干细胞标记物CD24、CD44v6的表达并探讨其临床病理意义。方法:49例胃癌、20例癌旁组织、36例淋巴结转移灶及80例不同类型胃良性病例(浅表性胃炎10例,萎缩性胃炎15例,胃溃疡20例,胃息肉20例,胃腺瘤15例)标本常规制作石蜡包埋切片,CD24和CD44v6染色方法为EnVi-sion免疫组化法。结果:胃癌病例CD24和CD44v6表达阳性率明显高于癌旁组织和不同类型胃良性病变(P<0.05或P<0.01),且阳性表达的良性病例胃黏膜上皮均呈中至重度不典型增生;转移灶CD24和CD44v6表达与相应原发灶呈现高度一致性(P>0.05);组织学分级Ⅱ级、无淋巴结转移及无远处器官转移胃癌病例CD24和CD44v6表达阳性率明显低于组织学分级Ⅲ或Ⅳ级、淋巴结转移及远处器官转移病例(P<0.05)。此外,浸润深度T1-T2及淋巴结N1站转移病例CD24表达阳性率明显低于浸润深度T3-T4和淋巴结N2、N3站转移病例(P<0.05)。结论:CD24和CD44v6表达可能是反映胃癌发生、进展、生物学行为和预后的重要癌干细胞标记物,检测胃良性病例CD24和CD44v6表达水平对预防和早期发现胃癌可能有一定的临床价值。
作者 姚宏亮 杨竹林 李永国
机构地区 中南大学湘雅二医院普外科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2008年第8期1629-1631,共3页 Chinese Journal of Pathophysiology
关键词 胃肿瘤 胃炎 CD24 CD44V6 Stomach neoplasms Gastritis CD24 CD44v6
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献17

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共引文献7

同被引文献38

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引证文献3

二级引证文献25

中国病理生理杂志
2008年 第8期

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