摘要
临床上欲了解肝病的病变程度通常需要评估肝功能,然而目前临床上仍缺乏安全、简便、准确、特异性好、重复性佳的肝功能检测手段。13C-乙酰胺甲氧基苯呼气试验(MBT)能定量评估细胞色素P450酶系统。以MBT评估组织学证实慢性肝病患者的乙酰胺甲氧基苯的O-脱烃作用,能准确反映肝损伤程度。MBT可区分早期肝硬化(Child-PughA)和无肝硬化患者。本文就MBT在肝功能评估中的作用作一综述。
Decision-making in severity of hepatic disease in clinics often requires the assessment of liver function, However, there is no safe, convenient, accurate method with high specificity and good reproducibility in the assessment of liver function.^13C-methacetin breath test （MBT） is thought to be a good method for quantitative evaluation of cytochrome P450 enzyme system, The rate of O-dealkylation of methacetin assessed by MBT in patients with histologically proven chronic liver disease was shown to accurately assess the degree of liver damage. MBT can reliably distinguish between early cirrhotic （Child-Pugh A） and non-cirrhotic patients, This article reviewed the role of MBT in the assessment of liver function.
出处
《胃肠病学》
2008年第7期443-445,共3页
Chinese Journal of Gastroenterology
