摘要
[目的]分析从住院患者中分离出的大肠埃希菌和肺炎克雷伯菌的耐药性变化,为临床合理使用抗生素提供依据。[方法]用常规方法分离鉴定病原菌,用K-B法做药物敏感试验。[结果]从2004～2006年,大肠埃希菌和肺炎克雷伯菌共检出781株,其中产超广谱β-内酰胺酶(ESBLs)菌占67.2%。3年中ESBLs总的检出率依次为51.6%,60.8%,78%,ESBLs的检出率呈逐年上升趋势。产超广谱β-内酰胺酶(ESBLs)的细菌对抗菌药物的耐药率明显高于不产ESBLs的细菌。[结论]本地区大肠埃希菌和肺炎克雷伯菌中产ESBLs的菌株检出率逐年上升,临床应严格合理使用抗菌药物,防止产ESBLs的大肠埃希菌和肺炎克雷伯菌在医院内暴发流行。
[ Objective] To analyze the change of drug resistance of Escherichia colt and Klebsiella pneumoniae isolated from the inpatients, so as to provide basis for rational utilization of antibiotics in clinic. [Methods] Pathogenic bacteria were isolated and identified by routine method, and drug sensitivity test was performed by Kirby-Bauer disk method. [ Results] From 2004 to 2006, a total of 781 strains of Escherichia colt and Klebsiella pneumoniae were detecte, out of them, ESBLs accounted for 67.2%. the total detection rate of ESBLs for recent three years were 51.6%, 60.8% and 78%, respectively, which should an increasing trend. The drug resistance rate of bacteria which could produce ESBLs was significantly higher than those could not produce ESBLs. [Gonclusion] The detection rates of Escherichia colt and KlebsieUa pneumoniae which could produce ESBLs in this area showed to be an increasing trend recently. It should be reasonable utilization of these antibacterials in clinic so as to prevent the outbreak of Escheriehia colt and Klebsiella pneumoniae which could produce ESBLs in hospital.
出处
《现代预防医学》
CAS
北大核心
2008年第16期3138-3140,共3页
Modern Preventive Medicine
关键词
大肠埃希菌
肺炎克雷伯菌
耐药性
Escherichia coli
Klebsiella pneumoniae
Drug resistance
