摘要
目的:分析影响肝门部胆管癌术后预后的因素。方法:对1997～2003年经手术切除的临床病例资料齐全的86例肝门部胆管癌患者进行研究,选择可能影响预后的8个临床病理学因素,将其对总体生存时间的影响进行单因素分析,并通过Cox比例风险模型进行多因素分析。结果:单因素分析显示,淋巴结转移(χ2=7.968,P=0.005)、肿瘤组织学分级(χ2=7.576,P=0.023)和神经浸润(χ2=5.504,P=0.019)影响肝门部胆管癌的预后;Cox风险比例模型多因素分析结果显示,淋巴结转移和神经浸润是影响肝门部胆管癌切除术后预后的独立因素。结论:影响肝门部胆管癌患者切除术后预后的独立因素是淋巴结转移和神经浸润。
OBJECTIVE： To analyse the factors which influence the prognosis of patients with hilar cholangiocarcinoma after resection. METHODS： The clinical data of 86 patients with hilar cholangiocarcinoma receiving resection in our hospital from 1997 to 2003 were collected retrospectively and the clinicopathological factors that might influence overall survival were analysed. A multivariate analysis was performed through Cox proportional hazard model. RESULTS： The single factor analysis showed that the major significant factors influencing the survival of these patients were histological type of the cancer（Х^2=7.576,P=0.023）, lymph node metastasis （Х^2= 7. 968,P=0. 005）, and perineural infiltration（Х^2= 5. 504,P= 0. 019）. Lymph node metastasis and perineural infiltration were found to be the independent factors influencing the overall survival by multivariate analysis through the Cox model. CONCLUSION： The most important prognostic factors for hilar holangiocarcinoma after resection are lymph node metastasis, and perineural infiltration.
出处
《中华肿瘤防治杂志》
CAS
2008年第15期1173-1175,1200,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
胆管肿瘤/外科学
比例危险度模型
预后
bile duct neoplasms/surgery
proportional hazards nodels
prognosis
