摘要
乳腺癌是女性发病率最高的肿瘤,严重威胁着女性的健康甚至生命。尽管手术、化疗和放疗手段有了长足的进步,大多数的患者仍然最终出现复发、转移,致使治疗失败。细胞增殖与凋亡的失衡是肿瘤发生机制之一,并且与肿瘤细胞的转移和耐药相关。抗凋亡基因在打破这一平衡的过程中发挥着重要的作用,因此抗凋亡基因成为了肿瘤治疗中的一个潜在的靶点。凋亡基因/蛋白的表达与乳腺癌发生、发展及分化、转移、预后的关系及相互作用机制的阐明,将进一步为乳腺癌的治疗及预后评估提供理论依据。
Breast cancer is the most common cancer in the female, which severely threatens their health and lives. Although significant improvements in surgery, chemotherapy and radiotherapy have been achieved, most patients with breast cancer inevitably suffer recurrence and metastasis. The imbalance between cell proliferation and apoptosis, as one of the oncogenesis mechanisms, has proved to be associated with metastasis and drug resistance. Anti-apoptosis genes play an important role in breaking this balance, so they become a potential target for cancer therapy. The elucidation of the interaction mechanism among all kinds of apoptosis associated genes or proteins and the relationship between these genes or proteins and breast cancer oncogenesis, development, differentiation, metastasis and prognosis will provide theoretical basis for further treatment and prognosis evaluation of breast cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2008年第14期837-840,共4页
Chinese Journal of Clinical Oncology
关键词
乳腺癌
凋亡
基因
Breast cancer
Apoptosis
Gene
