摘要
观察沙鼠肾细胞Ⅰ型灭活疫苗的中期流行病学效果。方法：采用间接免疫荧光抗体法（IFA）、微量细胞变性中和试验（MCPENT），分别检测荧光抗体及中和抗体；调查接种组与对照组人群发病情况。结果：自1994年10月以来的两年中，接种组发病1例（轻型），发病率为9．27／10万；对照组发病问例，发病率为161.98／10万，保护率为94．28％。流行高峰前（1996年10月）、后（1997年3月）新出现荧光抗体阳性4人，均无任何临床表现。结论：该疫苗有良好的中期防病效果；接种人群不存在免疫增强现象。
From October 1994 2 years' observation op the population innoculated with tyPe Ⅰinactivated vaccine (prepared from tissue culture of Mongolian gerbils kidney supplied by Institute of Biological Products, shanghai) showed that there was 1 case in the innoculated group, the morbidity rate was 9. 27/100 000, 17 cases in the control group, the morbidity rate was 16. 198/ 100 000 and the protection rate was 94. 28 %. The results indicated that the middle-term protection efficacy of the vaccine be sound.The case in the innoculated group was a patient of light-tyPe spoptom. Before epidemic peak (in October 1996) and after epidemic peak (in March 1997), 4 of the innoculated population had seroconversion of immunofluorescent antibody by IFA, but they had no clinical symptom. These showed that the vaccine didn't cause antibody dependent immunization enhancement.
出处
《中国媒介生物学及控制杂志》
CAS
CSCD
1997年第5期336-339,共4页
Chinese Journal of Vector Biology and Control
关键词
肾综合征出血热
灭活疫苗
流行病学效果
Hemorhagic fever with renal syndrome (HFRS)
Inactivated vaccine
Epidemiological efficacy
Antibody dependent immunization enhancement
