摘要
细胞因子诱导的杀伤细胞(CIK细胞)是由多种细胞因子,如干扰素γ、重组白细胞介素2、抗CD3McAb等诱导而成的对多种肿瘤具有杀伤活性的细胞毒性T细胞,具有高效的非主要组织相容性复合物限制性溶瘤活性,被认为是抗肿瘤过继细胞免疫治疗的新希望。本文综述了CIK细胞的特点、杀瘤机制和临床应用现状。
Cytokine-induced killer cells are cytotoxic T cells against various tumors, which induced by several cytokines such as IFN-γ, rIL-2, CD3McAb and so on. Their highly efficient tumoricidal effects are non-MHC restricted ,which was considered to be hopeful in application for adoptive cellular immunotberapy. This article reviewed the characteristics, mechanisms, research progress and clinical application of CIK cells.
出处
《医学综述》
2008年第15期2264-2266,共3页
Medical Recapitulate
基金
国家自然科学基金(30672335)
广东省自然科学基金(06027977)
深圳市科技局重点基金(200601008)
关键词
杀伤细胞
过继免疫治疗
肿瘤
Killer cells
Adoptive immunotherapy
Tumor
