摘要
目的考察黄芪注射液与全营养混合液配伍的稳定性。方法按临床常用的配伍方案,将黄芪注射液与全营养混合液配伍,通过光阻法、显微计数法两种方法同时测定混合液中不溶性微粒的数量、pH值;用激光衍射粒度分析仪测定乳剂颗粒的大小及粒径分布;HPLC-ELSD法测定TNA中黄芪甲苷的含量。结果黄芪注射液与全营养混合液配伍后,测得pH值低温组为(5.87±0.02),室温组为(5.88±0.09),混合液中不溶性微粒的数量符合药典标准;脂肪乳剂颗粒直径在低温组为(0.297±0.0049)μm,室温组为(0.297±0.0047)μm;黄芪甲苷的含量48 h内RSD1.81%。结论黄芪注射液与全营养混合液配伍后,上述观测结果稳定。
Ailn To investigate the compatible stability of Astragalus mongholicus injection in TNA. Methods To mix the Astragalus mongholieus injection with TNA by general clinical compatibility program, determine the quantity of insoluble particulate and pH by light blockage method and microscopic count method, determine particulate magnitude and grain size＇s distribution of emulsion by laser diffraction particle size analysator, and determine the astragaloside Ⅳ by HPLC-ELSD. Results The PH of low temperature group was （ 5.70 ± 0. 02 ） and ordinary temperature group was （5.69 ± 0. 01 ）. The insoluble particulate quantity was consistent with Ph. Standard. The particulate diameter of fat emulsion was （ 0. 297 ± 0. 0049 ）μm in low temperature group and （ 0. 297 ± 0. 0047 ）μm in ordinary temperature group. The RSD% of astragaloside Ⅳ was 1.81% within 48 h. Conclusion The observed results indicated that Astragalus mongholieus injection was stable in TNA.
出处
《安徽医药》
CAS
2008年第8期688-690,共3页
Anhui Medical and Pharmaceutical Journal
关键词
黄芪注射液
全营养混合液
配伍
astragalus mongholicus injection
TNA
compatibility
