摘要
对乳酸环丙沙星在腹膜透析液中的长期稳定性进行了研究。乳酸环丙沙星按２５ｍｇ／Ｌ加入腹膜透析液中，在５℃、３７℃和室温（２６～２８℃）条件下，在０、０．５、１、２、３、５、７、１０、１４、２１、２８、３５、５１ｄ取样，用紫外分光光度法在２７５ｎｍ处测定了环丙沙星的浓度，结果表明乳酸环丙沙星在腹膜透析中对上述条件下均稳定。
The long term stability of ciprofloxacin in peritoneal dialysis solution was studied.Ciprofloxacini lactas was added to nine 1-L bags of dialysis solution to yield a nominal concentration of 25 mg/L,Three bags each were stored at 5℃,37℃and room temperature(26～28℃),The samples were taken from each bag after 0、0.5、1、2、3、5、7、10、14、21、28、35、51 days and concentrations were analyzed by ultraviolet spectrophotometry(275±1)nm.The percentage of change in ciprofloxacin concentration was 1.5%after storage at 5℃,1.9% after storage at 27℃ and 3.0%after storage at 37℃,The results indicate that Ciprofloxlcini lactas is stable for 51 days when stored at three conditions above.
出处
《华西药学杂志》
CAS
CSCD
北大核心
1996年第3期155-157,共3页
West China Journal of Pharmaceutical Sciences
关键词
环丙沙星
腹膜透析液
稳定性
Ciprofloxacin Peritoneal dialysis solution Stablily Ultraviolet spectrophotometry
