摘要
目的探讨超重或肥胖的2型糖尿病（T2DM）患者空腹血浆胰岛素（FINS）及游离脂肪酸（FFA）水平变化。方法选取263例T2DM患者，按体质指数分为正常体重组（108例）、超重和肥胖组（155例），并与72例正常对照组比较。采用化学发光法测定FINS水平，FFA水平采用比色法测定。结果T2DM组较正常对照组FINS水平明显升高[（6．18±1．86）mIU／L与（4．60±2．58）mIU／L，P〈0．01]；FFA水平明显升高[（0．58±0．25）mmol／L与（0．35±0．14）mmol／L，P〈0．01]。超重或肥胖组血FINS水平[（7．20±1．99）mIU／L]与正常体重组[（5．31±1．21）mIU／L]、正常对照组[（4．60±2．58）mIU／L]比较，差异有统计学意义（P〈0．01）。T2DM组FINS水平与病程（r=0．334，P〈0．01）、体质指数（r=0．532，P〈0．01）及舒张压（r=0．342，P〈0．01）呈正相关。结论超重或肥胖T2DM患者FINS水平显著高于正常体重T2DM患者，T2DM患者血FFA水平显著高于正常对照组，二者参与了胰岛素抵抗及T2DM的发生发展。
Objective To investigate the fasting plasma insulin （FINS） and free fatty acid （ FFA） in overweight or obesity patients with type 2 diabetes mellitus （ T2DM ） Methods 263 patients of T2DM were selected and divided into normal weight group（ n = 108 ） and overweight or obesity group（ n = 155 ） according to body mass index （ BMI ）, FINS level was detected by chemiluminescence method , and FFA level by colorimetry. 72 subjects without T2DM were taken as controls. Results FINS [ （6.18 ± 1.86）mIU/L vs （4.60 ±2.58） mIU/L,P〈0.01） ] and FFA[ C0.58 ± 0.25 ） mmol/L vs C0.35±0.14） mmol/L,P 〈 0.01） ] in T2DM group was significantly higher than that of control group. FINS in overweight or obesity group [ （ 7.20± 1.99 ） mIU/L ] was higher than that in normal weight group [ （ 5.31 ± 1.21 ） mIU/L ] and control group [ （ 4.60±2.58 ） mIU/L ] （ P 〈 0.01 ）. In T2DM group, FINS was positively correlated with duration （ r = 0. 334, P 〈 0.01 ）, BMI （ r = 0. 532, P 〈 0.01 ） and diastolic pressure （ DBP ） （ r = 0. 342,P 〈 0.01 ）. Conclusion The FINS level in overweight or obesity patients with T2DM is significantly higher compared to T2DM with normal weight T2DM, and the FFA level in patients of T2DM is significantly higher increased compared to control group,both of which participate in insulin resistence as well as the occurrence and development of T2DM.
出处
《中国综合临床》
北大核心
2008年第8期792-794,共3页
Clinical Medicine of China
关键词
2型糖尿病
胰岛素
游离脂肪酸
肥胖
Type 2 diabetes mellitus
Insulin
Free fatty acid
Obesity
