摘要
目的研究生脉散中五味子醇甲在大鼠体内药物代谢动力学规律。方法大鼠灌胃给予生脉散2.16g/kg,在不同的时间点采血样,用HPLC法测定五味子醇甲浓度的经时变化,以3p97药代动力学软件进行分析,计算药动学参数。结果五味子醇甲在大鼠体内药动学参数分别是:t1/2(Ka)为0.245 h,t1/2(Ke)为1.506h,T(peak)为0.767h,Cmax为0.926mg·L-1,AUC为2.863mg·L-1·h-1。结论生脉散中五味子醇甲可吸收进入体内,其在体内吸收和消除速度均比较快,符合线性动力学规律。
Objective To study the pharmacokinetics of schizandrin in Shengmai powders in normal rats. Methods After ig administration of the drug（ 2.16 g/kg ）for the rats ,the plasma was collected at different time points. The schizandrin in Shengmai powders and in the plasma were analyzed by HPLC. Pharmaconetic parameters were calculated from the plasma concentration - time data with the 3p97 software package. Results The main pharmacokinetic parameters were as follows： t1/2 （Ka） was 0. 245 hour,t1/2 （Ke） was 1. 506 hour , T（peak） was 0. 767 hour, Cmax was 0. 926 mg · L^-1, AUC was 2. 863 mg · L^-1· h^- 1. Conelusion The schizandrin in Shengmai powders can be absorbed into body, and its absorption and elimination is rapid. The pharmaconetics of plasma schizandrin complies with linear kinetic course.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第7期1626-1627,共2页
Lishizhen Medicine and Materia Medica Research
基金
湖北大学中药生物技术省重点实验室开放基金课题(No.20060202)
