摘要
目的:制备复方鱼腥草分散片,以黄芩苷为指标考察体外溶出度。方法:以分散均匀性为考察指标,采用正交设计试验对分散片的处方工艺进行筛选和优化。结果:优化处方的崩解剂组成为CMS-Na5%,MCC20%,L-HPC10%,制备的分散片分散均匀性符合中国药典规定,3min累积溶出百分数达95%以上。结论:试验研制的复方鱼腥草分散片处方工艺简单可行。
Objective： To prepare the compound Yuxingcao dispersible tablets and investigate the dissolution of baicalin in vitro. Methods： The formulation of dispersible tablets was optimized by an orthogonal design test in terms of disinterating time. Results： The optimal disintegrants were composed of CMS- Na 5%, MCC 20%, L-HPC 10%, and disintegration time of prepared compound Yuxingcao dispersible tablets followed the quality specification of dispersible tablet in Chinese Pharmacopoeia 2005. The in vitro dissolution test indicated that more than 95% of baicalin dissolved in 3 minute from dispersible tablets. Concolusion： The formulation and preparation process of compound Yuxingcao dispersible tablets were simple and feasible.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2008年第8期740-742,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
关键词
复方鱼腥草分散片
处方优化
溶出度
Compound Yuxingcao dispersible tablet
Formulations optimization
Dissolution
