摘要
目的了解既往未诊断为糖尿病的人群糖代谢与肺功能损害的相关性。方法用112例既往未诊断为糖尿病的健康查体者的体检结果计算第1秒末用力呼吸量(FEV1.0)、用力肺活量(FVC)及第1秒末用力呼气量/用力肺活量(FEV1.0/FVC)实测值与其预计值的差值(分别定义为rFEV1.0、rFVC及rFEV1.0/FVC),再用线性回归方法分别计算它们与空腹血糖、餐后2 h血糖及糖化血红蛋白是否呈线性相关。结果随着空腹血糖、餐后2 h血糖及糖化血红蛋白的增高,rFEV1.0及rFVC均呈现线性下降(P<0.01),但rFEV1.0/rFVC却无此趋势。结论血糖标记物水平的增高是导致肺功能损害的一个高危因素。
Objective To investigate the relationship between the glucose metabolism and lung function in an adult population without a clinical diagnosis of diabetes. Methods We analyzed the physical examination results of 112 cases without a clinical diagnosis of diabetes and calculate the FEV1.0, FVC and FEV1.0/FVC ; and the value of residual pulmonary function was determined by subtracting the predicted from the measured value, respectively. The relationship between the glucose metabolism status （fasting plasma glucose, serum glucose level 2 hours after a glucose load and glycosylated hemoglobin ） and residual pulmonary function value were analyzed using multiple linear regression, respectively. Results The glucose metabolism status was negatively associated with the rFEV1.0 and rFVC, but there was no relationship with rFEV1.0/rFVC. Conclusion The glucose metabolism status may be a risk factor, which contributes to the reduction of lung function.
出处
《河北医药》
CAS
2008年第7期943-944,共2页
Hebei Medical Journal
关键词
糖尿病
肺功能
血糖
diabetes mellitus
pulmonary function
serum glucose
