摘要
建立了人血清中环丙沙星的微生物测定法,平均回收率为101.2%,日内误差CV为4. 5%,以该法对患者进行了环丙沙星的稳态药物动力学研究,体内过程符合一室模型.其主要药物动力学参数为 T_(max)=0.96±0.44h;(C_∞)_(max)=2.73±1.02μg/ml;T_(1/2)=5.14±1.13h;Vd/F=6.62±4.18L/kg;Cl/F=0.89±0.52L/(kg·h).
A microbiological method was developed for the determination of ciprofloxacin serum concentration and used to study the steady pharmacokinetics of it. The average recov-ery was 101. 2%, CV Was 4. 5%. Ciprofloxacin in vivo were fitted to one compartment mod-el. It's main pharmacokinetic parameters are as follow:T'p (0.96 ±0. 44)h;C_(∞max)(2.73 ±1.02)μg/ml;T(1/2)(5.14±1. 13)h;Vd/F (6. 62±4.18)L/kg;Cl/F (0. 89±0. 52)L/(kg ·h).
出处
《中国临床药学杂志》
CAS
1997年第3期109-111,共3页
Chinese Journal of Clinical Pharmacy
关键词
微生物法
环丙沙星
药物动力学
microbiological assay
ciprofloxacin
pharmacokinetics
