摘要
八例男性健康志愿者交叉口服二个厂家生产的盐酸环丙沙星作药代动力学研究。用高效液相色谱法和微生物法测定血、尿标本。结果两种盐酸环丙沙星都于服药后1小时达到高峰浓度,其中HPLC测定浓度分别为1.995、1.759mg/L;微生物测定浓度为2.332、2.121mg/L。盐酸环丙沙星在体内代谢药一时曲线符合二房室模型。半衰期为5.7小时。肾清除率占总体消除率的40％～50％,24小时内两种产品原型药物在尿中的回收率分别为52.5％、40.2％。该药的肾清除率为25L/h,两种环丙沙星药代动力学特征基本相似,统计学处理无显著性差异(P>0.05)。
The Pharmacokinetic study of Ciprofloxacin was performed in 8 normal volunteers.According to the cross-over design, every volunteer was given two products of Ciprofloxacin respectively, which produced by different pharmaceutical factory. Blood and urine samples were measured by both HPLC and agar diffusion method.
The serum course of Ciprofloxacin could be best described by a two-c ompartment model.Maximal serum concentrations were attained 1 hour after dosing. The elimination half-life of Ciprofloxacin was 5.7 hour. High volumes of distribution(exceeding 94 liters/62.5 kg) suggested effective diffusions and combinations of Ciprofloxacin in the extravascular tissue. The kidney clearance of Ciprofloxacin was 25 liters/hour, which was much greater than the normal rate of glomecular filtration and indicates that tubular secretion contributes to renal excretion.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1993年第5期349-352,共4页
Chinese Journal of Antibiotics
关键词
环丙沙星
药代动力学
抗菌系
药理
Ciprofloxacin
Pharmacokinetics
HPLC
Microbiological assay
