摘要
综述了基因工程菌在手性醇合成中的研究情况。介绍了合成手性醇的酶学研究及酶的基因特性,重点阐述了工程菌的质粒构建及表达体系对不对称合成的催化效率和立体选择性的影响,并对基因工程菌不对称还原制备手性醇的应用前景进行了展望。
The recent progress of asymmetric synthesis of chiral alcohol with genetic engineering strain is reviewed.Characterization of reductases and reductases gene is introduced.The effects of plasmid construction and expression system upon the capability of stereo-selective reduction are emphasized.The prospect of applications of genetic engineering strain and the problems existing in the process of construction are also presented.
出处
《化工进展》
EI
CAS
CSCD
北大核心
2008年第7期977-982,共6页
Chemical Industry and Engineering Progress
基金
浙江省科技厅重大科技项目(2005C13034)
关键词
基因工程菌
生物催化
不对称还原
手性醇
genetic engineering strain
biocatalysis
asymmetric reduction
chiral alcohol
