期刊文献+

5-羟甲基噻唑合成工艺的研究进展 被引量:8

Progress on Synthetic Technologies of 5-Hydroxymethylthiazole
下载PDF
导出
摘要 5-羟甲基噻唑是合成第二代抗AIDS药物利托那韦的中间体。综述了近二十年来5-羟甲基噻唑的合成工艺。 Great attentions were paid to 5-hydroxymethyhhiazole, an intermediate in the synthesis of the second generation of anti-AIDS drug ritonavir. The synthetic technologies of 5-hydroxymethylthiazole were reviewed in this paper.
出处 《精细化工中间体》 CAS 2008年第3期12-14,共3页 Fine Chemical Intermediates
关键词 5-羟甲基噻唑 合成工艺 研究进展 5-hydroxymethyhhiazole synthetic technologies progress
  • 相关文献

参考文献26

  • 1Kollonitsch J. Processes for preparing thiazole carboxylic acid [P]. US: 3 299 083, 1967-01-17. 被引量:1
  • 2Durant G J, Emmett J C, Ganellin C R. Pharmacologically active guanidine compounds in compositions and methods of use [P]. US: 4 154844, 1979-05-15. 被引量:1
  • 3Hatanaka M, Ishimaru T. Synthetic penicillins. Heterocyclic analogs of ampicillin. Structure-activity relations [J ]. Med. Chem, 1973, 16 (9): 978. 被引量:1
  • 4Mcmurryn T B, Mcblhinney R S, Mccormick J E, et al. O^6- substituted guanine derivatives, a process for their preparation and their use in treating tumour cells[P]. US: 6 043 228, 2000- 03-28. 被引量:1
  • 5John D G, Colin E J, Robin G C. Pharmacologically active guanidine compounds[P]. US: 3 950 333, 1976-04-13. 被引量:1
  • 6Coulton S, Hadley M S, Herdon H J, et al. Broadspectrum heterocyclic substituted phenyl containing sulfonamide HIV protease inhibitors[P]. US: 20 050 222 215, 2005-10-06. 被引量:1
  • 7Vazquez M J, Mueller R A, Talley J J, et al. α-And-β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors[P]. US : 20 070 078 173, 2007-04-05. 被引量:1
  • 8Peter A C, Cynkowskl T, Cynkowska G, et al. Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids[P]. US: 7 214 710, 2007-05-08. 被引量:1
  • 9Barrish J C, Das J, Kanner S B, et al. Thiazolyl inhibitors of tee family tyrosine kinases[P]. US : 7 241 781, 2007-07-10. 被引量:1
  • 10Kempf D J, Norbeck D W, Sham H L, et al. Retroviral protease inhibiting compounds[P]. WO: 9 414 436, 1994-07-07. 被引量:1

二级参考文献15

  • 1黄宪 陈振初.有机合成化学[M].北京:化学工业出版社,1981.494. 被引量:2
  • 2[1]Cregg R J,Herrmann J L.A convenient one flask procedure for ester alky-lation[J].Tetrahedron Lett.,1973,(26):2 425-2 428. 被引量:1
  • 3[2]Hurd R N,Shah D H.Stobbe condensations of dimethyl 3,5-bis(benzyloxy)hom-ophthalate[J].J.Org.Chem.,1973,38(3):607-609. 被引量:1
  • 4[3]Klein J,Levene R.Stereochemistry of the nucleophilic substitution of vi-nylic bromides with copper[J].J.Amer.Chem.Soc.,1972,94:2 520-2 521. 被引量:1
  • 5[4]Corey E J.A method for stereospecific synthesis of 1,3-and 1,4-dienes viaorganocopper[J].J.Amer.Chem.Soc.,1972,94(12):4 395-4 397. 被引量:1
  • 6[6]Zimmer R,Ziemer A,Gruner M.Siloxy cyclopropane sin ugi four component reaction:A new method for the synthesis of highly subsitituted pyrrolidi-none derivatives[J].Synthesis,2001,(11):1 649-1 658. 被引量:1
  • 7[7]Fieser M,Fieser L.Reagents for organic synthesis[M].United States:JohnWiley & Sons,Inc.1967.581. 被引量:1
  • 8[9]Cerny M,Málek J.Properties of sodium-bis-(2-methoxyethoxy) aluminiumhyd-ride.Ⅷ.Reduction and hydrogenolysis of some hydroxysubstituted aromaticaldehydes,carboxylic acids,esters and carbinols[J].Tetrahedron Lett.,1969,(22):1 739-1 742. 被引量:1
  • 9[10]Kempf D J,Norbeck D W.Sham H L,et al.Retroviral Protease Inhibiting Compounds [P].USP:5541206,1996. 被引量:1
  • 10[11]Wang Y,Liu L W,L'Heureux A,et al.Preparation of Chloromethylpyridine Hydrochlorides[P].USP:5942625,1999. 被引量:1

共引文献3

同被引文献63

引证文献8

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部