摘要
综述了替莫唑胺作用机理、给药方式、合成方法、衍生物的合成及生物活性,对其合成方法和衍生物的生物活性进行分析比较发现,5-重氮基咪唑-4-甲酰胺与异氰酸甲酯反应是较好的合成替莫唑胺方法,8-位酰胺类衍生物有较好的肿瘤抑制作用。
The action mechanism, administral approaches, synthesis methods and biological activity of temozolomide derivatives were summarized in this article. It was found by comparison that synthesis of temozolomide from the reaction of 5-diazoimidazole -4-carboxamide with methyl isocyanatewas was a good way, and 8-carboxamide derivative of temozomide had the higher inhibitory activity against tumour.
出处
《精细化工中间体》
CAS
2008年第3期1-5,共5页
Fine Chemical Intermediates
基金
贵州省科技厅资助项目(黔科合NY字[2006]3041)
关键词
替莫唑胺
作用机理
合成方法
衍生物
生物活性
temozolomide
activity mechanism
synthesis
derivative
biological activity
