摘要
目的通过不同的试验方法和不同的溃疡模型观察银耳多糖抗溃疡作用的途径和机制。方法①采用两种给药方式研究银耳多糖对应激型溃疡的作用途径。②对消炎痛型溃疡的作用和其与前列腺素(PGE2)的关系。③对慢性醋酸型胃溃疡的影响。④对幽门结扎型胃溃疡的影响,同时检测胃液量、总酸、游离酸和胃蛋白酶活力。结果①银耳多糖主要通过局部作用抑制应激型溃疡的形成,末次给药1h后做诱导溃疡试验,试验组溃疡划级为1.85±0.83,对照组为4.29±1.01,两组之间有非常显著差异(P<0.001),末次给药12h后做诱导溃疡试验,试验组溃疡划级为3.32±0.97,对照组为4.23±0.81,两组之间无显著差异(P>0.05)。②对消炎痛型溃疡有抑制作用,与对照组比较两组之间有显著差异(P<0.05),对前列腺素无影响。③对慢性醋酸型溃疡有显著抑制作用,与对照组比较,两组之间有非常显著差异(P<0.01)。④对幽门结扎型溃疡有显著抑制作用,与对照组比较,两组之间有非常显著差异(P<0.001),银耳多糖的制酸效应和抑制胃蛋白酶活力,分别与对照组比较两组之间有非常显著差异(P<0.001)。结论银耳多糖对大鼠应激型溃疡,慢性醋酸型溃疡,幽门结扎型溃疡和消炎痛型溃疡均有抑制作用,以前三项作用强。其作用机制以制酸为主,并有保护胃黏膜和抑制胃蛋白酶活力的作用。
Objective To investigate the approach and mechanism of antiulcer effect of tremella polysaccharide with different test methods and different ulcer models. Methods （1）Two methods of medicine administering were used to investigate the approach of effect of tremella polysaccharide on the stress ulcer. （2） The effect on and indomethacin ulcer and the relationship to prostaglandin E2 （PGE2） were investigated. （3）The effect on the chronic acetic acid gastric ulcer was investigated. （4）The effect on the pyloric ligation gastric ulcer and the gastric juice volume, total acid output, free acid and pepsin activity were investigated, Results （1）The tremella polysaccharide inhibited the formation of the stress ulcer mainly with local effect. The ulcer induced test was performed one hour after the medicine was administered for the last time. The criterion was 1.85± 0.83 in the test group and 4.29± 1.01 in the control group, There was significant difference between the two groups （P〈0.001）. The ulcer induced test was performed 12 hours after the medicine was administered for the last time. The criterion was 3.32± 0.97 in the test group and 4.23± 0.81 in the control group. There was no significant difference between the two groups （P〉0.05）, （2）The tremella polysaccharide could inhibit the indomethacin ulcer and there was significant difference with the control group （P〈0.05）. The tremella polysaccharide had no effect on prostaglandin, （3）The tremella polysaccharide could significantly inhibit the chronic acetic acid ulcer and there was significant difference with the control group （P〈0.01）. （4）The tremella polysaccharide could significantly inhibit the pyloric ligation ulcer and there was significant difference with the control group （P〈0.001）. There were significant differences in the acid inhibition effect and the pepsin activity between the two groups （P〈0.001）, Conclusion The tremella polysaccharide can inhibit the stress ulcer, the chronic acetic a
出处
《中国疗养医学》
2008年第5期316-318,共3页
Chinese Journal of Convalescent Medicine
关键词
银耳多糖
胃溃疡模型
前列腺素
Tremella polysaccharide
Gastric ulcer model
Prostaglandin
