摘要
目的:观察通关丸对小鼠前列腺增生模型的抑制作用及相关机制。方法:80只小鼠随机分为正常对照组、模型组、普乐安组和通关丸组,每组20只。各组大鼠皮下注射丙酸睾丸素5g(/kg·d)建立前列腺增生动物模型。正常对照组、模型组给予生理盐水灌胃,普乐安组给予普乐安混悬液1.9g/kg灌胃,通关丸组给予通关丸水煎液10g/kg灌胃。每1次,共31d。末次给药后剖取前列腺称重,计算指数;分光光度法测定血清酸性磷酸酶(PACP)活性;放射免疫法测定血清睾酮(T)水平。结果:通关丸能显著降低小鼠前列腺湿重、前列腺指数、血清PACP活性及血清T水平,改善前列腺组织病理学变化,具有明显的抗炎、镇痛作用。结论:通关丸可治疗前列腺增生,其机制可能与降低血清PACP活性、调节性激素水平等有关。
Objective：To observe the effect and mechanism of Tongguan pill on prostate hyperplasia.Methods ： 80 mice were randomly divided into normal group,model group,Tongguan pill treatment group,pule＇an tablet treatment group. The prostate hyperplasia mice models were established by subcutaneous injection of testosterone.The weight of prostate was measured, the activity of PACP was detected by spectrophotometry, the serum T level was measured by radio-immunoassay. Results：Tongguan pill could significantly decrease the weight and index of prostate, the activity of PACP and serum T level.Conclusions ：Tongguan pill has therapeutic effect on prostate hyperplasia through decreasing the activity of PACP and regulating the sex hormone level.
出处
《山西中医学院学报》
2008年第3期10-11,共2页
Journal of Shanxi College of Traditional Chinese Medicine
关键词
通关丸
前列腺增生
抑制作用
Tongguan pill,prostate hyperplasia,inhibition effect
