摘要
目的:观察六磨沉香散化裁治疗老年前列腺增生的临床疗效及对患者PSAD和TGF-β1的影响。方法:选取我院收治的94例老年良性前列腺增生患者,使用随机分组的方法将其分为对照组和观察组,两组各47例,对照组使用常规西药坦索罗辛,观察组在此基础上使用六磨沉香散化裁,两组均治疗6个月。比较两组临床疗效,观察两组患者残余尿量(RU)、最大尿流率(Qmax)和前列腺体积(PV),检测两组患者治疗前后前列腺特异抗原(PSA)、前列腺特异抗原密度(PSAD)和转化生长因子(TGF-β1),对比两组患者治疗前后前列腺症状评分(IPSS)和中医症状积分,记录两组患者治疗过程中的不良反应。结果:对照组总有效率为74.47%,观察组总有效率为87.23%,高于对照组(P<0.05),对照组患者各项指标均得以改善,观察组与之相比效果更为显著(P<0.05),且观察组不良反应发生率为21.28%,低于对照组的不良反应发生率36.17%(P<0.05)。结论:六磨沉香散化裁结合常规西药对治疗老年前列腺增生的疗效及安全性优于单纯使用西药。
Objective: To study the clinical efficacy of Modified Liumo Chenxiang Powder in the treatment of elderly patients with benign prostatic hyperplasia(BPH) and its effect on PSAD and TGF-beta 1.Methods: 94 elderly patients with benign prostatic hyperplasia in our hospital were randomly divided into controlled group and observation group,47 cases in each group.The controlled group was treated with tamsulosin,while the observation group was treated with Liumo Chenxiang Powder for 6 months.The clinical effects of the two groups were compared.The residual urine volume(RU),maximum urinary flow rate(Qmax) and prostate volume(PV) of the two groups were observed.The prostate specific antigen(PSA),prostate specific antigen density(PSAD) and transforming growth factor(TGF-β1) were measured before and after treatment.The prostate symptom score(IPSS) and TCM symptom score of the two groups before and after treatment were compared and recorded.Adverse reactions during treatment were observed in both groups.Results: The total effective rate of the controlled group was 74.47%,and that of the observation group was 87.23%,higher than that of the controlled group(P < 0.05).The indexes of the patients in the controlled group were improved,and the effect of the observation group was more significant than that of the controlled group(P < 0.05).The incidence of adverse reactions in the observation group was 21.28%,which was lower than that of the controlled group 36.17%(P < 0.05).Conclusion: The efficacy and safety of Liumo-chenxiang Powder combined with conventional western medicine in the treatment of elderly patients with benign prostatic hyperplasia is better than that of simple western medicine.
作者
张梨林
杜晓丹
杨菲
杨文黎
HANG Lilin;DU Xiaodan;YANG Fei(Department of Geriatrics,Sichuan Second Hospital of Traditional Chinese Medicine,Chengdu Sichuan 610014,China)
出处
《四川中医》
2019年第12期123-126,共4页
Journal of Sichuan of Traditional Chinese Medicine
