摘要
[目的]探讨矽肺患者及接尘工人诱导痰中白细胞介素-6(IL-6)、白细胞介素-16(IL-16)含量变化及其意义。[方法]测定110名矽尘接触工人、54例矽肺患者、32名无矽尘接触史的后勤人员诱导痰中IL-6I、L-16含量和肺活量(VC)、用力肺活量(FVC)、第一秒用力呼气量(FEV1)、第一秒用力呼气量占预计值的百分比(FEV1/FVC)及最大用力呼气流速(PEF),并进行IL-6I、L-16与接尘工龄和以上肺功能指标的相关性分析。[结果]3组研究对象诱导痰中IL-6含量差异无统计学意义(P>0.05);矽肺患者和接尘工人组诱导痰中IL-16含量高于对照组(P<0.05、P<0.01),接尘组与病例组间IL-16含量差异无统计学意义(P>0.05)。矽肺患者和接尘工人诱导痰中IL-6、IL-16水平与接尘工龄无相关性(P>0.05)。IL-6与FEV1/FVC呈明显的负相关(P<0.05);IL-16与FVC、FEV1、FEV1/FVC、PEF皆呈明显的负相关(P<0.05)。[结论]诱导痰中IL-16含量可以反映矽尘所致的肺组织炎症反应。
[Objective]To study the changes of sputum IL-6, IL-16 and its significance in pneumosilicosis patients and workers exposed in dust. [Methods]110 workers exposed in dust were Selected,54 pneumosilicosis patients,32 workers who are not exposed in dust were selected as control group;Sputum IL-6,IL-16 and pulmonary function （VC; FVC; FEV1 ;FEV1/FVC;PEF）was detected; The relationship of both length of service and pulmonary function with IL-6 and IL-16 were analyzed. [Results]The level of induction sputum IL-6 was not different in three groups （ P〉0.05）,The concentration of induction sputum IL-16 in patients group and workers group were higher than that in control group（ P〈0.05; P 〈0.01） ,sputum IL-16 was not difference between patients group and workers group（ P 〉0.05）. There was no relationship between sputum IL-6 ,IL-16 and length of service （ P〉0.05）. Sputum IL-6 had a positive relationship with FEV1/FVC （ P G0.05） ;Sputum IL-16 had an evident positive relationship with FVC, FEV1, FEV1/FVC, PEF （ P 〈0.05）. [Conclusion]The level of sputum IL-16 may preferably reflect the level of inflammation in lung tissue which caused by silicosis.
出处
《预防医学论坛》
2008年第7期583-585,588,共4页
Preventive Medicine Tribune
基金
山东省卫生厅计划课题(项目号:2005HW164)
关键词
矽肺
诱导痰
IL-6
IL-16
肺功能
Pneumosilicosis
Induction sputum
IL-6
IL-16
Pulmonary function
