摘要
叶酸受体广泛分布在正常组织及肿瘤组织中,不同点在于多数肿瘤细胞叶酸受体的数量和活性远远超过正常细胞,而且叶酸受体在正常细胞呈极性分布,恶变后失去极性,使血液循环中的药物可接触到该受体,借以将药物靶向导入癌细胞。如今,叶酸受体已成为肿瘤靶向的理想配体。
Folate receptor distributes in normal tissues and tumor organization widely, but the quantities and activities of folate receptor is higher in tumor cells than those in normal cells. Moreover, the folate receptor assumes the polar distribution in the normal cell, and loses its polarity when the receptor becomes malignant ,which may result in the medicine in the blood circulation entering into the targeted tumor cells by contacting folate receptors. At present, Folate receptor has become the ideal ligand for targeted therapy of tumor.
出处
《医学综述》
2008年第13期2041-2043,共3页
Medical Recapitulate
关键词
叶酸受体
靶向治疗
肿瘤
Folate receptors
Targeting therapy
Tumor
