摘要
目的探讨叶酸受体介导的宫颈特殊染色法在宫颈癌及癌前病变筛查中的应用价值。方法选取2014年1月-2015年7月来医院就诊的患者同时行FRD宫颈特殊染色检测、液基细胞学(TCT)检测,两者任一项提示异常(FRD提示阳性、细胞学提示AGC或≥LSIL)者行阴道镜检查,以病理结果为金标准,比较两者临床诊断价值。结果纳入病例204例,在宫颈癌及癌前病变的筛查中FRD特殊染色、TCT检查两种检验技术敏感度分别为91.20%、84.00%,特异性分别为62.03%、63.29%,诊断符合率分别为79.90%、75.98%,阳性预测值分别为79.17%、78.36%,阴性预测值分别为81.67%、71.43%,Kappa值分别为0.56、0.48。FRD特殊染色与TCT检查结果差异无统计学意义(P>0.05)。结论 FRD特殊染色、TCT检查两种检验技术在宫颈病变中的筛查意义无明显差异,但FRD特殊染色操作简便、结果快速、成本低廉,值得应用于临床。
Abstract： Objective To explore the application value of folic acid receptor-mediated cervical special staining in screening of cervical cancer and cervical precancerous lesion. Methods The patients with one abnormal result of cervical special staining or TCT （ positive cervi-＇ cal special staining result, cytology test indicated AGC or≥ LSIL） treated in the hospital from Janaury 2014 to July 2015 were selected; pathological result was designed as gold standard ; the clinical diagnostic values of the two method were compared. Results A total of 204 cases were included; the sensitivities of cervical special staining and TCT were 91.20% and 84. 00%, respectively; the specificities were 62. 03% and 63.29 %, respectively; the diagnostic coincidence rates were 79. 90% and 75.98%, respectively; the positive predictive val- ues were 79. 17% and 78. 36%, respectively; the negative predictive values were 81.67% and 71.43%, respectively; Kappa values were 0.56 and 0. 48, respectively. There was no statistically significant difference between cervical special staining and TCT （P〉0.05） . Con- clusion There was no statistically significant difference between cervical special staining and TCT in screening of cervical lesions, but cervi- cal special staining is easier, faster, and cheaoer, which is worthy of clinical application.
出处
《中国妇幼保健》
CAS
2016年第4期835-837,共3页
Maternal and Child Health Care of China
基金
北京市科委项目(D151100001915001)
关键词
叶酸受体介导
宫颈特殊染色
宫颈癌
宫颈癌前病变
筛查
Folic acid receptor-mediated
Cervical special staining
Cervical cancer
Cervical precancerous lesion
Screening
