摘要
目的:研究IκBα与核因子κB(NF-κB)在胃癌组织中的表达,了解细胞内IκBα水平的变化对NF-κB活性的影响。方法:62例胃癌患者术后切取胃癌组织及癌旁正常胃黏膜组织,用免疫印迹法对胃癌组织及正常胃黏膜组织中IκBα与NF-κB表达进行配对研究。结果:59例胃癌组织中细胞浆IκBα水平表达下降,伴随细胞核NF-κB活性增强(P<0.01),3例胃癌组织中IκBα及NF-κB活性与正常胃黏膜组织中无统计学意义。结论:胃癌组织细胞浆内IκBα水平下降有利于NF-κB异常活化。
Objective： To study the expression of inhibitor kappaBa（IκBα）and nuclear factor kappaB（NF-κB）in gastric carcinoma tissues and the influence of IκBα level on the activity of NF-κB. Methods： Western blot was used to examine the expression of IκBα and NF-κB in gastric carcinoma tissues and adjacent normal gastric mucosal tissues. The results were analyzed by comparing study. Results： Analyzed by comparing study, in 59 cases, the level of IκBα in cytoplasm decreased and the NF-κB expression in nucleoplasm increased, however in 3 cases there was no significant difference. Conclusion： The degradation of IκBα in cytoolasm is essential for the aberrant activation of NF-κB.
出处
《汕头大学医学院学报》
2008年第2期90-92,共3页
Journal of Shantou University Medical College
基金
广东省科技厅资助项目(2003C30307)
关键词
胃癌
IΚBΑ
核因子ΚB
gastric carcinoma
inhibitor kappaBα
nuclear factor kappaB
